HBS WITH SHORTER POLYPEPTIDE CHAINS DUE TO ...

HBS WITH SHORTER POLYPEPTIDE CHAINS DUE TO DELETIONS OF ONE-TO-FIVE AMINO ACID RESIDUES

Hb Name	Residues	Deletions
Boyle Heights	alpha6(A4)	Asp->0
Taybe	alpha38(C3) or alpha39(C4)	Thr->0
Natal	alpha140(HC2)-alpha141(HC3)	Tyr-Arg->0

Leiden	beta6(A3) or beta7(A4)	Glu->0
Lyon	beta17(A14)-beta18(A15)	Lys-Val->0
Freiburg	beta23(B5)	Val->0
Higashitochigi (or HT)	beta24(B6) or beta25(B7)	Gly->0
Bruxelles	beta41(C7) or beta42(CD1)	Phe->0
Niteroi	beta43(CD2)-beta45(CD4)	Glu-Ser-Phe->0
	OR	OR
	beta42(CD1)-beta44(CD3)	Phe-Glu-Ser->0
Tochigi	beta56(D7)-beta59(E3)	Gly-Asn-Pro-Lys->0
Saint-Antoine	beta74(E18)-beta75(E19)	Gly-Leu->0
Vicksburg	beta75(E19)	Leu->0
Tours	beta87(F3)	Thr->0
Gun Hill	beta91(F7)-beta95(FG1)	Leu-His-Cys-Asp-Lys->0
Coventry	beta141(H19)	Leu->0^a

^a Recent information has shown that leucine in Hb Atlanta-Coventry is not deleted but oxidized to hydroxyleucine. The same possibility should be considered for Hb Coventry.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.