Hb Villeparisis	beta77(EF1)His->Tyr;
	beta80(EF4)Asn->Ser

HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves very close to Hb A at alkaline pH and has a lower pI than Hb A
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		The betaX and betaA chains separate by reversed phase HPLC; tryptic digestion of AE-betaX chain; separation of peptides by reversed phase HPLC; amino acid analysis; mass spectrometry
DNA ANALYSES		Not reported; presumed mutations CAC->TAC and AAC->AGC at codons 77 and 80
FUNCTION STUDIES		Not reported
STABILITY		Not reported
OCCURRENCE		Found in a French male
OTHER INFORMATION		The beta77 His->Tyr replacement is specific for Hb Fukuyama

REFERENCES
1.		Wajcman, H., Promé, D., Blouquit, Y., Riou, J., Préhu, C., Bardakdjian, J., and Galacteros, F.: Br. J. Haematol., 87:65 (Suppl. 1), 1994.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.