Hb Arlington Park	beta6(A3)Glu->Lys;
	beta95(FG2)Lys->Glu

HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A do not separate by standard methodology at both alkaline and acidic pH
CHROMATOGRAPHY		Not done
STRUCTURE STUDIES		Tryptic digestion of AE-betaX+betaA chains; separation of peptides by cation exchange chromatography; sequencing
DNA ANALYSES		Not reported; presumed mutations GAG->AAG and AAG->GAG at codons 6 and 95
FUNCTION STUDIES		Not done
STABILITY		Not reported
OCCURRENCE		Observed in a 47-year-old Black male suffering from hypertension who died due to a cerebro-vascular accident a few days after admission to hospital; there are no living blood relatives
OTHER INFORMATION		Accidentally observed when sample was used as a control for peptide mapping; the beta6 Glu->Lys mutation is characteristic for Hb C and beta95 Lys->Glu for Hb N-Baltimore

REFERENCES
1.		Adams, J.G., III and Heller, P.: Hemoglobin, 1:419, 1977.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.