Hb A2-Fitzroy	delta142(H20)Ala->Asp

CONTACT		External; central cavity; 2,3-DPG pocket
ELECTROPHORESIS		Hb X moves between Hb S and Hb A2 at alkaline pH
IEF		About the same
CHROMATOGRAPHY		Hb X was isolated by DEAE-Sephadex chromatography
STRUCTURE ANALYSIS		Tryptic digestion of Hb X; separation of peptides by fingerprinting; amino acid analysis; sequencing
DNA ANALYSIS		Not reported; presumed mutation GCC->GAC at codon 142
NOTES		Found in a Greek family

REFERENCES
1.		Williamson, D., Brennan, S.O., Strosberg, H., Whitty, J., and Carrell, R.W.: Hemoglobin, 8:325, 1984.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.