Hb Vancouver	beta73(E17)Asp->Tyr

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; Hb X moves slightly ahead of Hb S; no separation at acidic pH
CHROMATOGRAPHY		Hb X was isolated by DEAE-Sephadex chromatography
STRUCTURE STUDIES		Tryptic digestion of AE-betaX chain; separation of peptides by cation exchange chromatography; amino acid analysis; chymotrypsin
DNA ANALYSES		Not reported; presumed mutation GAT->TAT at codon 73
FUNCTION STUDIES		Decreased oxygen affinity; normal Bohr effect, cooperativity, and 2,3-DPG effect
STABILITY		Normal
OCCURRENCE		Found in a family from Canton, China living in Canada
OTHER INFORMATION		Found in association with beta-thal; quantity in the heterozygote 40%

REFERENCES
1.		Jones, R.T., Brimhall, B., Pootrakul, S., and Gray, G.: J. Mol. Evol., 9:37, 1976.
2.		Gray, G.R. and Marion, R.B.: Hemoglobin, 2:143, 1978.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.