Hb Vaasa	beta39(C5)Gln->Glu

CONTACT		alpha1beta2 contact
HEMATOLOGY		Mild hemolytic anemia in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; Hb X moves to a position slightly faster than Hb A
CHROMATOGRAPHY		Hb X was isolated by DEAE-cellulose chromatography; Hb X elutes approximately as Hb F
STRUCTURE STUDIES		Tryptic digestion of betaX chain; cation exchange chromatography; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation CAG->GAG at codon 39
FUNCTION STUDIES		Not performed
STABILITY		Slightly unstable
OCCURRENCE		Found in members of a Finnish family
OTHER INFORMATION		Quantity in the heterozygote 33.1%

REFERENCES
1.		Kendall, A.G., ten Pas, A., Wilson, J.B., Cope, N., Bolch, K., and Huisman, T.H.J.: Hemoglobin, 1:292, 1977.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.