Hb Tunis	beta124(H2)Pro->Ser

CONTACT		External; alpha1beta1 contact
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		No separation by conventional techniques; in IEF Hb X moves just ahead of Hb A
CHROMATOGRAPHY		No separation reported; the betaX and betaA chains separate in reversed phase HPLC (elution order: betaA, betaX, alpha)
STRUCTURE STUDIES		Tryptic digestion of AE-betaX chain; separation of tryptic peptides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation CCA->TCA at codon 124
FUNCTION STUDIES		Normal
STABILITY		Normal
OCCURRENCE		Found in members of a Tunisian family
OTHER INFORMATION		Quantity in the heterozygote ~45%

REFERENCES
1.		Mrad, A., Blouquit, Y., Lacombe, C., Blibech, R., Arous, N., Bardakdjian, J., Kastally, R., Rosa, J., and Galacteros, F.: Hemoglobin, 12:23, 1988.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.