Hb Randwick	beta15(A12)Trp->Gly

CONTACT		Internal; A-E helices spacer
HEMATOLOGY		Normal in the heterozygote; mild reticulocytosis
ELECTROPHORESIS		Hb X moves faster than Hb A on cellulose acetate at alkaline pH; Hb X and Hb A can be separated by IEF
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion of betaX chain; fingerprinting by reversed phase HPLC; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation TGG->GGG at codon 15
FUNCTION STUDIES		Normal
STABILITY		Unstable
OCCURRENCE		Found in members of a Northern Italian family
OTHER INFORMATION		Quantity in the heterozygote estimated at 48-50%

REFERENCES
1.		Gilbert, A.T., Fleming, P.J., Sumner, D.R., Hughes, W.G., Ip, F., Kwan, Y.L., and Holland, R.A.B.: Hemoglobin, 12:149, 1988.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.