Hb Rambam	beta69(E13)Gly->Asp

ALSO KNOWN AS		J-Cambridge
CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; Hb X moves faster than Hb A
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		ryptic digestion; separation of peptides by fingerprinting; chymotryptic digestion; amino acid analysis; leucine amino peptidase
DNA ANALYSES		Not reported; presumed mutation GGT->GAT at codon 69
FUNCTION STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in a Bedouin family from Israel and an English family
OTHER INFORMATION		Quantity in the heterozygote not reported

REFERENCES
1.		Salomon, H., Tatarski, I., Dance, N., Huehns, E.R., and Shooter, E.M.: Israel J. Med. Sci., 1:836, 1965.
2.		Sick, K., Beale, D., Irvine, D., Lehmann, H., Goodall, P.T., and MacDougall, S.: Biochim. Biophys. Acta, 140:231, 1967.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.