Hb Ocho Rios	beta52(D3)Asp->Ala

CONTACT		External
HEMATOLOGY		Normal in the heterozygote; a few target cells
ELECTROPHORESIS		Hb X and Hb A can be separated at alkaline and acidic pH; Hb X moves like Hb S
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; chymotryptic digestion
DNA ANALYSES		Not reported; presumed mutation GAT->GCT at codon 52
FUNCTION STUDIES		Not reported
STABILITY		Not reported
OCCURRENCE		Found in a Black Jamaican male
OTHER INFORMATION		Found in association with Hb S

REFERENCES
1.		Beresford, C.H., Clegg, J.B., and Weatherall, D.J.: J. Med. Genet., 9:151, 1972.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.