Hb Moscva	beta24(B6)Gly->Asp

CONTACT		Internal; close contact with the E helix
HEMATOLOGY		Hemolytic anemia with reticulocytosis in the heterozygote
ELECTROPHORESIS		Hb X and Hb A can be separated at alkaline pH; Hb X moves faster than Hb A
CHROMATOGRAPHY		Hb X was isolated by DEAE-Sephadex chromatography
STRUCTURE STUDIES		Tryptic digestion; fingerprinting; amino acid analysis; thermolysin digestion; sequencing
DNA ANALYSES		Not reported; presumed mutation GGT->GAT at codon 24
FUNCTION STUDIES		Slightly decreased oxygen affinity; small change in Bohr effect and cooperativity
STABILITY		Unstable
OCCURRENCE		Found in a few members of a Russian family
OTHER INFORMATION		Quantity in the heterozygote not determined

REFERENCES
1.		Idelson, L.I., Didkowsky, N.A., Casey, R., Lorkin, P.A., and Lehmann, H.: Nature, 249:768, 1974.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.