Hb Mequon	beta41(C7)Phe->Tyr

CONTACT		Heme contact
HEMATOLOGY		Severe hemolytic crisis during viral infection; treated with acetaminophen; Heinz bodies present at this time; past general health excellent; macrocytosis and reticulocytosis
ELECTROPHORESIS		No separation reported
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; fingerprinting; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation TTC->TAC at codon 41
FUNCTION STUDIES		Normal
STABILITY		Unstable
OCCURRENCE		Found in a female of English-Irish extraction
OTHER INFORMATION		Quantity in the heterozygote ~40-50% by amino acid analysis

REFERENCES
1.		Burkert, L.B., Sharma, V.S., Pisciotta, A.V., Ranney, H.M., and Bruckheimer, S.: Blood, 48:645, 1976.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.