Hb Machida	beta6(A3)Glu->Gln

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves with the mobility of Hb S by IEF
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; fingerprinting; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GAG->CAG at codon 6
FUNCTION STUDIES		Normal
STABILITY		Not reported
OCCURRENCE		Found in a Japanese family
OTHER INFORMATION		Quantity in the heterozygote 40-43%

REFERENCES
1.		Harano, T., Harano, K., Ueda, S., Shibata, S., Imai, K., and Seki, M.: Hemoglobin, 6:531, 1982.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.