Hb K-Ibadan	beta46(CD5)Gly->Glu

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves faster than Hb A at alkaline pH; no separation at acidic pH
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; fingerprinting or reversed phase HPLC for peptide separation; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GGG->GAG at codon 46
FUNCTION STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in an African Yoruba adolescent and in an Italian family
OTHER INFORMATION		Quantity in the heterozygote 28-33%

REFERENCES
1.		Allan, N., Beale, D., Irvine, D., and Lehmann, H.: Nature, 208:658, 1965.
2.		Castagnola, M., Cassiano, L., Rossetti, D.V., Marucci, L., Ferro, A., Scarano, C., Monaco, M., and Celozzi, A.M.: Hemoglobin, 14:647, 1990.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.