Hb J-Lens	beta13(A10)Ala->Asp

CONTACT		External
HEMATOLOGY		Probably normal in the heterozygote
ELECTROPHORESIS		Hb X moves to the position of Hb J on cellulose acetate at alkaline pH
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; Edman degradation
DNA ANALYSES		Not reported; presumed mutation GCC->GAC at codon 13
FUNCTION STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in a 2-year-old French child; no report of a family study
OTHER INFORMATION		Quantity in the heterozygote ±50%

REFERENCES
1.		Djoumessi, S., Rousseaux, J., and Dautrevaux, M.: FEBS Lett., 136:145, 1981.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.