Hb J-Chicago	beta76(E20)Ala->Asp

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; Hb X moves faster than Hb A
CHROMATOGRAPHY		Hb X was isolated by DEAE-Sephadex chromatography
STRUCTURE STUDIES		Tryptic digestion of AE-betaX chain; separation of peptides by fingerprinting; amino acid analysis; chymotrypsin
DNA ANALYSES		Not reported; presumed mutation GCT->GAT at codon 76
FUNCTION STUDIES		Normal
STABILITY		Normal
OCCURRENCE		Found in a 2-year-old Black male living in Chicago, Illinois, USA
OTHER INFORMATION		Quantity in the heterozygote 51.6%

REFERENCES
1.		Romain, P.L., Schwartz, A.D., Shamsuddin, M., Adams, J.G., III, Mason, R.G., Vida, L.N., and Honig, G.R.: Blood, 45:387, 1975.

---

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.