Hb Howick	beta37(C3)Trp->Gly

CONTACT		alpha1beta2 contact
HEMATOLOGY		Mild erythrocytosis in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at both alkaline and acidic pH; Hb X moves like Hb S or Hb D at high pH, and like Hb F at low pH
CHROMATOGRAPHY		Hb X was isolated by DEAE-Sephadex chromatography
STRUCTURE STUDIES		Tryptic digestion; fingerprinting; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation TGG->GGG at codon 37
FUNCTION STUDIES		Slightly increased oxygen affinity; reduced Bohr effect
STABILITY		Normal
OCCURRENCE		Found in one adult of unnamed racial or ethnic background
OTHER INFORMATION		Quantity in the heterozygote 29%

REFERENCES
1.		Owen, M.C., Ockelford, P.A., and Wells, R.M.G.: Hemoglobin, 17:513, 1993.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.