Hb Hirose	beta37(C3)Trp->Ser

CONTACT		alpha1beta2 contact
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves between Hb S and Hb F at alkaline pH
CHROMATOGRAPHY		Hb X was isolated by CM-cellulose chromatography; Hb X elutes between Hb A and Hb A2
STRUCTURE STUDIES		Tryptic digestion; fingerprinting; amino acid analysis; specific staining for tryptophan
DNA ANALYSES		Not reported; presumed mutation TGG->TCG at codon 37
FUNCTION STUDIES		Increased oxygen affinity; decreased Bohr effect and cooperativity
STABILITY		Normal
OCCURRENCE		Found in a few Japanese families
OTHER INFORMATION		Quantity in the heterozygote 41.4%; dissociates into dimers in the liganded state

REFERENCES
1.		Yamaoka, K.: Blood, 38:730, 1971.
2.		Fujita, S.: J. Clin. Invest., 51:2520, 1972.
3.		Ohba, Y., Hattori, Y., Fuyuno, K., Takeda, I., Matsuoka, M., Yoshinaka, H., Satoh, T., and Miyaji, T.: Hemoglobin, 7:191, 1983.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.