Hb Hazebrouck	beta38(C4)Thr->Pro

CONTACT		Heme contact
HEMATOLOGY		Hemolytic anemia with reticulocytosis; Heinz bodies
ELECTROPHORESIS		Not detectable with standard methodology; Hb X moves slightly slower than Hb A by IEF
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion of betaX chain; fingerprinting and reversed phase HPLC; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation ACC->CCC at codon 38
FUNCTION STUDIES		Decreased oxygen affinity
STABILITY		Mildly unstable
OCCURRENCE		Observed in a French male
OTHER INFORMATION		Quantity in the heterozygote estimated at 31%; hemichrome formation

REFERENCES
1.		Blouquit, Y., Delanoe-Garin, J., Lacombe, C., Arous, N., Cayre, Y., Peduzzi, J., Braconnier, F., and Galacteros, F.: FEBS Lett., 172, 155, 1984.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.