Hb Hamadan	beta56(D7)Gly->Arg

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH (Hb X occupies the position of Hb S)
CHROMATOGRAPHY		Hb X was isolated by DEAE-cellulose chromatography
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation GGC->CGC at codon 56
FUNCTION STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in three members of an Iranian family, a French Caucasian family, and in four members of a family of Turkish descent
OTHER INFORMATION		Quantity in the heterozygote 40%

REFERENCES
1.		Rahbar, S., Nowzari, G., Haydari, H., and Daneshmand, P.: Biochim. Biophys. Acta, 379:645, 1975.
2.		Dinçol, G., Aksoy, M., Dinçol, K., Kutlar, A., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 8:423, 1984.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.