Hb Crete	beta129(H7)Ala->Pro

CONTACT		Internal
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A do not separate with standard techniques; Hb X moves ahead of Hb A by IEF
CHROMATOGRAPHY		Hb X was isolated on a Bio-Rex 70 column
STRUCTURE STUDIES		Tryptic digestion of betaX chain; separation of peptides by fin-gerprinting; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GCC->CCC at codon 129
FUNCTION STUDIES		Increased oxygen affinity; decreased cooperativity; normal Bohr effect
STABILITY		Unstable
OCCURRENCE		Found in three members of a Greek family living in New York
OTHER INFORMATION		Found in combination with betao- and (deltabeta)o-thal

REFERENCES
1.		Maniatis, A., Bousios, Th., Nagel, R.L., Balazs, T., Ueda, Y., Bookchin, R.M., and Maniatis, G.M.: Blood, 54:54, 1979.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.