Hb Camden	beta131(H9)Gln->Glu

ALSO KNOWN AS		Tokuchi; Motown
CONTACT		Internal; alpha1beta1 contact
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; Hb X moves faster than Hb A; at acidic pH Hb X moves close to Hb F
CHROMATOGRAPHY		Hb X and Hb A separate by cation and anion exchange chromatography
STRUCTURE STUDIES		Tryptic digestion of AE-betaX chain; separation of peptides by fingerprinting or cation exchange chromatography; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation CAG->GAG at codon 131
FUNCTION STUDIES		Normal oxygen affinity
STABILITY		Normal
OCCURRENCE		Found in several Black families and in a Japanese family
OTHER INFORMATION		Quantity in the heterozygote 35-46%; found in combination with Hb S and with alpha-thal

REFERENCES
1.		Wade-Cohen, P.T., Yates, A., Bellingham, A.J., and Huehns, E.R.: Nature, 243: 467, 1973.
2.		Hubbard, M., Wilson, J.B., Wrightstone, R.N., Efremov, G.D., and Huisman, T.H.J.: Acta Haematol., 54:53, 1975.
3.		Ohba, Y., Miyaji, T., Matsuoka, M., Ueda, S., Iuchi, I., and Shibata, S.: Acta Haematol. Jap., 38:1, 1975.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.