Hb Baden	beta18(A15)Val->Met

CONTACT		Internal
HEMATOLOGY		Unknown; the mutation resulting in this variant occurred on a chromosome with the beta+-thal mutation IVS-I-5 (G->C)
ELECTROPHORESIS		Not observed
CHROMATOGRAPHY		Hb X and Hb A separate incompletely by cation exchange HPLC; the betaX and betaA chains do not separate in reversed phase HPLC
STRUCTURE STUDIES		Not done; structural analyses by DNA sequencing
DNA ANALYSES		A GTG->ATG mutation at codon 18
FUNCTION STUDIES		Not reported
STABILITY		Not reported
OCCURRENCE		Found in a mother and son from East Germany
OTHER INFORMATION		None

REFERENCES
1.		Divoky, V., Bissé, E., Wilson, J.B., Gu, L-H., Wieland, H., Heinrichs, I., Prior, J.F., and Huisman, T.H.J.: Biochim. Biophys. Acta, 1180:173, 1992 .

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.