Hb Alabama	beta39(C5)Gln->Lys

CONTACT		alpha1beta2 contact
HEMATOLOGY		Mild anemia in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; Hb X moves to the position of Hb S
CHROMATOGRAPHY		Hb X was isolated by DEAE-Sephadex chromatography; Hb X elutes between Hb A and Hb A2
STRUCTURE STUDIES		Tryptic digestion; cation exchange chromatography; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CAG->AAG at codon 39
FUNCTION STUDIES		Not performed
STABILITY		Not performed
OCCURRENCE		Found in a Black family from Alabama, USA
OTHER INFORMATION		Quantity in the heterozygote 38%

REFERENCES
1.		Brimhall, B., Jones, R.T., Schneider, R.G., Hosty, T.S., Tomlin, G., and Atkins, R.: Biochim. Biophys. Acta, 379:28, 1975.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.