Hb Aalborg	beta74(E18)Gly->Arg

CONTACT		Internal
HEMATOLOGY		Mild anemia in the heterozygote; Heinz bodies
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; Hb X has a mobility between that of Hb F and Hb S
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion of betaX chain; peptides were characterized by FAB mass spectrometry
DNA ANALYSES		Not reported; presumed mutation GGC->CGC at codon 74
FUNCTION STUDIES		Not reported
STABILITY		Mildly unstable
OCCURRENCE		Found in a 7-year-old girl and her father
OTHER INFORMATION		Quantity in the heterozygote ~21%

REFERENCES
1.		Williamson, D., Nutkins, J., Rosthoj, S., Brennan, S.O., Williams, D.H., and Carrell, R.W.: Hemoglobin, 14:137, 1990.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.