Hb Karlsruhe	beta28(B10)Leu->Met

CONTACT		Internal
HEMATOLOGY		No details provided; methemoglobinemia
ELECTROPHORESIS		Hb X moves like Hb F at alkaline pH; not detectable by IEF
CHROMATOGRAPHY		No separation by cation exchange HPLC
STRUCTURE STUDIES		Not reported
DNA ANALYSES		ACTG->ATG mutation at codon 28
FUNCTION STUDIES		MetHb level ~8%
STABILITY		Unstable
OCCURRENCE		Found in several members of a family from Southern Germany
OTHER INFORMATION		None

REFERENCES
1.		Seelig, H.P.: Personal communication, 1995.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.