Hb Aubenas	beta26(B8)Glu->Gly

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves slower than Hb A at alkaline pH
CHROMATOGRAPHY		Hb X and Hb A readily separate in cation exchange HPLC
STRUCTURE STUDIES		Tryptic digestion of AE-betaX chain; separation of peptides by HPLC; amino acid analysis; mass spectrometry
DNA ANALYSES		A GAG->GGG mutation at codon 26
FUNCTION STUDIES		Normal
STABILITY		Mildly unstable
OCCURRENCE		Found in a French family
OTHER INFORMATION		Quantity in the heterozygote 39%; in vitro chain synthesis alpha/(betaA+betaX) 0.96; no thalassemic features

REFERENCES
1.		Lacan, P., Francina, A., Promé, Galactéros, F., and Wajcman, H.: Hemoglobin, 20:113, 1996.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.