Welcome to the Globin Gene Server

This site provides data and tools for studying the function of DNA sequences, with an emphasis on those involved in the production of hemoglobin. It includes information about naturally-occurring human hemoglobin mutations and their effects, experimental data related to the regulation of the beta-like globin gene cluster, and software tools for comparing sequences with one another to discover regions that are likely to play significant roles.

General:

  Introduction
  Documents describing this WWW server
  How this site supports functional genomics
  Images of models and results
  Log of updates
  How to contact us

Human Hemoglobin Mutations:

  HbVar database
         A relational database of Hb variants and thalassemias, initially derived
         from Prof. Huisman's Syllabi (see next links) and regularly updated.
  A Syllabus of Human Hemoglobin Variants (1996)
  Most of  A Syllabus of Thalassemia Mutations (1997)

Database of Experimental Results on Gene Expression:

  dbERGE II

Genome Annotation:

  Gala: Genome Alignment and Annotation Database

Sequence Analysis of Genomic DNA:

Pairwise alignments 
  PipMaker: Percent Identity Plots
  PipTools: create PipMaker annotations and analyze output  latest release: 2003-Nov-04 (C), 2003-Jul-08 (Perl)
  Whole genome human/mouse alignments
  Laj alignment viewer  latest release: 2005-Dec-14
  Static diagrams, plus descriptions of loci  
Multiple alignments 
  MultiPipMaker
  EnteriX: alignments of E. coli and selected enteric bacteria
  DNA sequences from the beta-like globin gene clusters of several mammals
  A multiple alignment of those sequences
  Sample images from a multiple alignment
  Tools for finding conserved regions in multiple alignments  
Miscellaneous 
  Restriction site utilities

Publications and Software:

(Please see our publications page.)

Course Materials:

  Fall 2002: BIO/CSE/STAT 597/8F
  Spring 2002: BIO/CSE/STAT 597/8F
  Fall 2001: CSE/BIO 597F
  Fall 2001: IBIOS lecture
  Fall 2000: CSE/BIO 597F
  Spring 2000: BMMB/CSE 597D

Links to Related Sites:

  Hemoglobins, globin genes, and hemoglobinopathies
  Genomes and genome analysis
  Local sites

This service is provided by laboratories of Computer Science & Engineering and Biochemistry & Molecular Biology at the Pennsylvania State University. It is supported by PHS grants R01 LM05773 and R01 LM05110 from the National Library of Medicine.