After adjusting the tracks displayed on the Genome Browser, you can see that
the Hispanic thalassemia deletion (among two others) removes noncoding,
intergenic DNA that has several characteristics of gene regulatory regions.
As indicated by the outlined box, the deleted regions (long blue rectangles)
show several peaks of evolutionary conservation (dark blue track) that
correspond to DNase I hypersensitive sites (HSs, red tracks) associated with
hyperacetylated histones in chromatin (black tracks) in an erythroid cell line
(K562). The FAIRE signals (lower green tracks) are also a reflection of
accessible chromatin. The prominent signals in the ENCODE data correspond to
the several hypersensitive sites (HS1, HS2, HS3, and HS4) in the locus control
region, which is needed for high-level expression of all beta-like globin genes
(including HBE1) in erythroid cells. Known regulatory regions in this locus
are shown in the green custom track at the top
(data set,
instructions).
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