Example 1 (continued)

The default settings at UCSC will bring up the Genome Browser as shown here, unless you have used it before (and haven't cleared your cookies). However, the default tracks may not convey the most relevant information. You will generally want to use the Browser's "configure" button to customize which tracks are displayed, and the gray and blue boxes on the side to further tune the display as desired.

For example, the default view shows that the 39,808 bp deleted in the Hispanic thalassemic chromosome removes an olfactory receptor gene (OR51B4), but it is hard to imagine how that could lead to a substantially reduced synthesis of beta-globin. This quandary can be resolved by bringing up more tracks of functional information from the ENCODE project and expanding the view, as described on the next page.

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